1. α-Diversity metrics: (A) observed operational taxonomic units (OTUs) and (B) phylogenetic diversity (PD whole tree) were greater in the mucosa and tumour microbiota of patients with colon cancer compared with the non-cancer control mucosa at colonoscopy. β-diversity: (C) within-group weighted UniFrac dissimilarity) was lower for colon cancer mucosa or tumour microbiota than control mucosa and (D) between-group dissimilarity was lowest for colon cancer mucosa versus tumour samples when compared with controls at colonoscopy.
α-Diversity metrics: (A) observed operational taxonomic units (OTUs) and (B) phylogenetic diversity (PD whole tree) were greater in the mucosa and tumour microbiota of patients with colon cancer compared with the non-cancer control mucosa at colonoscopy. β-diversity: (C) within-group weighted UniFrac dissimilarity) was lower for colon cancer mucosa or tumour microbiota than control mucosa and (D) between-group dissimilarity was lowest for colon cancer mucosa versus tumour samples when compared with controls at colonoscopy. False discovery rate (FDR)-corrected non-parametric t-test using 1000 Monte Carlo permutations; **FDR<0.01; *FDR<0.05.
Ashley A Hibberd et al. BMJ Open Gastroenterol 2017;4:e000145
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