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Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport  Britt–Marie Fihn, Anders Sjöqvist, Mats.

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Presentation on theme: "Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport  Britt–Marie Fihn, Anders Sjöqvist, Mats."— Presentation transcript:

1 Permeability of the rat small intestinal epithelium along the villus-crypt axis: Effects of glucose transport  Britt–Marie Fihn, Anders Sjöqvist, Mats Jodal  Gastroenterology  Volume 119, Issue 4, Pages (October 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Clearance of mannitol, Cr-EDTA, and inulin from luminal perfusates containing either 30 mmol/L mannitol or glucose (perfusion rate, 0.5 mL/min) and of mannitol and Cr-EDTA (perfusion rate, 0.2 mL/min). The mannitol values (perfusion rate, 0.5 mL/min) are the compiled data from the 51Cr-EDTA/14C-mannitol and 14C-mannitol/3H-inulin series. Bars denote ±SE. Significances between values and number of observations (n) are shown in Table 1. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Clearance of mannitol, Cr-EDTA, and inulin from luminal perfusates containing either 30 mmol/L mannitol or glucose during nicotinic receptor blockade by hexamethonium (10 μg/kg intravenously) administered every 45 minutes. The mannitol values are the compiled data from the 51Cr-EDTA/14C-mannitol and 14C-mannitol/3H-inulin series. Bars denote ±SE. Significances between values and number of observations (n) are shown in Table 2. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

4 Fig. 3 Relationship between net fluid transport and clearance of the different permeability probes in all series in this study. The exact values and SE values are shown in Tables 1 and 2. The linear regression equation for clearance of Cr-EDTA is y = 0.09x , for mannitol with KM solution y = 0.33x , and with KG solution y = 1.15x Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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