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Candida albicans Adds More Weight to Iron Regulation

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Presentation on theme: "Candida albicans Adds More Weight to Iron Regulation"— Presentation transcript:

1 Candida albicans Adds More Weight to Iron Regulation
Jill R. Blankenship, Aaron P. Mitchell  Cell Host & Microbe  Volume 10, Issue 2, Pages (August 2011) DOI: /j.chom Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Model for Niche-Dependent Functions of C. albicans Iron Regulators During growth in the bloodstream (top), transcription factors Sef1 and Hap43 are expressed and functional. Sef1 promotes expression of iron uptake genes and several virulence genes. Hap43 represses iron utilization genes and SFU1. During growth in the GI tract (bottom), transcription factor Sfu1 represses iron uptake genes and SEF1, thus indirectly repressing HAP43 as well. This state causes elevated expression of iron utilization genes. Cell Host & Microbe  , 93-94DOI: ( /j.chom ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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