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The Complex Cartography of Stem Cell Commitment

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1 The Complex Cartography of Stem Cell Commitment
Koichi Akashi, David Traver, Leonard I. Zon  Cell  Volume 121, Issue 2, Pages (April 2005) DOI: /j.cell Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Fate Map of Hematopoietic Stem Cell Commitment Based on the Differential Expression of the Sca-1 and c-Kit Cell Surface Receptors In the conventional model (A), the loss of myeloerythroid potential occurs abruptly when LSK cells produce CLPs, whereas a new model (B) predicts that LSK cells sequentially lose Meg/E and then G/M potential during lymphoid commitment. Cell  , DOI: ( /j.cell ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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