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Angelica Oviedo, MD, Erik K. Mont, MD, Philip D. Acott, MD 

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Presentation on theme: "Angelica Oviedo, MD, Erik K. Mont, MD, Philip D. Acott, MD "— Presentation transcript:

1 Radiology and Pathology in a Child With Calcification and Simplified Gyration 
Angelica Oviedo, MD, Erik K. Mont, MD, Philip D. Acott, MD  Pediatric Neurology  Volume 78, Pages (January 2018) DOI: /j.pediatrneurol Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Computed tomographic scan taken at day one of life shows symmetrical linear subcortical calcification of the frontal lobes. The lateral thalamus also shows marked calcification. The gyration appears simplified. The computed tomographic scans were adjusted using the levels and sharpen tools of Photoshop. Pediatric Neurology  , 80-81DOI: ( /j.pediatrneurol ) Copyright © 2017 Elsevier Inc. Terms and Conditions

3 Figure 2 Histologic section of the frontal lobe cortex and white matter shows extensive neuronal and white matter loss, poor myelination, and extensive calcification (arrows) at the gray-white junction seen as coarse purple bodies (A, taken at 4× magnification). The thalamus shows a large amount of calcification, seen as coarse purple bodies (B, taken at 10× magnification). Both slides: Hematoxylin, eosin, and luxol fast blue stain. High-resolution versions of these slides for use with the Virtual Microscope are available as eSlides: VM04350 (Cortex), VM04353 (Thalamus). The pons, VM04355, and cerebellar vermis, VM04356, are also available. (The color version of this figure is available in the online edition.) Pediatric Neurology  , 80-81DOI: ( /j.pediatrneurol ) Copyright © 2017 Elsevier Inc. Terms and Conditions


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