1. The Connecticut Institute for Clinical and Translational Science (CICATS)

2. What is CICATS?
The University of Connecticut, in partnership with regional hospitals, state agencies, and community health care organizations, has created the Connecticut Institute for Clinical and Translational Science (CICATS) to transform the way biomedical science is conceived, conducted and disseminated in Connecticut.

3. The Connecticut Institute for Clinical and Translational Science (CICATS)
CICATS Cores
Basic Science Education & Training
Biostatistics Gateway
Biomedical Informatics Pilot Program
Community Engagement Regulatory Support
Clinical Research Center Tracking & Evaluation

4. Investigator Resources
The Connecticut Institute for Clinical and Translational Science (CICATS)
CICATS Gateway
Investigator Resources

5. Mission
The Gateway is the “front door” for investigators seeking CICATS services and support.
We offer referrals, tools, information and programs for investigators initiating and planning clinical and translational research projects.
Goals
Inform, educate and engage
Networking and collaboration
Facilitate access to research services

6. One-stop Shopping Investigator Advocate Regulatory Analyst
Navigation
Referral and Consult
Team-building
Research Planning
Regulatory Analyst
Regulatory Core
Liaison to CICATS IRB
Technical Assistance on-site
Biostatistics Support
Biostatistics
Team with IA and RA to enhance research planning
Consulting and Services on-site

7. Services & Programs Research Support Referral and team development
Listserv, newsletter, website
Seminars and workshops
On-line toolkit
Design Laboratory

8. Research Toolkit
Research Process Guidance
Electronic tool
Coming Soon – Fall 2011

9. Research Toolkit

10. Design Laboratory
Feedback for Investigators Planning Clinical and Translational Research Proposals
Present proposal to expert panelists
Range of expertise, including study design and statistics
Presentation
Discussion
Written Feedback
Feedback
Investigator incorporates feedback into proposal
Gateway referral services as needed
Revisions

11. Networking & Collaboration
Profiles Research Networking Tool
Set up your profile and publication list
Search for research partners by expertise
Connect with other investigators

12. Profiles Research Networking Software

13. What is Translational Research?
Using knowledge from basic science to produce new drugs, treatments, or prevention strategies.
Moving treatments, interventions, or “best practices” to the public sector where they may be implemented to improve health.
Reduce the gap between discovery and practical application

14. Translational Research: The Spectrum
BENCH
PRACTICE
BEDSIDE
Basic Science Research
Preclinical Studies
Animal studies
Human Clinical Research
Controlled observational Studies
Phase 3 clinical trials
Clinical Practice
Delivery of recommended care
Identification of new questions T1
Phase 1,2
clinical trials T2
Practice-based Research
Phase 3, 4 trials
Observational studies
Survey Research
Guideline Development
Meta-analysis
Systematic review
Adapted from Westfall, J., Mold, J., Fagnan, L. (2007) Practice-Based Research: Blue Highways on the NIH Roadmap, JAMA 297 (4):
“T3” Dissemination & Implementation

15. Conclusion
The Gateway is and important resource for investigators or trainees seeking CICATS services or trying to navigate the research process.

16. CICATS Regulatory
Regulatory Resources

17. Mission
The overarching purpose of the Regulatory Core is the protection of human subjects and their protected health information (PHI).
Goals & Support:
Regulatory support
Regional CICATS IRB
Education & guidance
Clinical research ethics consulting

18. Conclusion
The CICATS Regulatory Core is available for assisting investigators in all matters of regulatory compliance.
Contact: Stacey Anderson
Phone:

19. CICATS Biostatistics Center
Biostatistics Services

20. Mission
The Biostatistics Center is the primary resource for providing biostatistical collaboration and support for researchers throughout the UConn Health Center and CICATS partner institutions
Goals
Provide support for grant development that leads to externally funded grants and ongoing research collaboration
Consult with researchers to identify best analysis strategies, study design and power analysis
Mentor students and physician-scientists in training
Provide statistical analysis services (fee for service)

21. Grant Development Statistical support leading to ongoing collaboration
Statistics Plan
Power Analysis & Sample Size
Complete “Statistical Considerations” Grant Sections
NIH and externally funded grants
Statistical support leading to ongoing collaboration

22. Consultations with researchers
Identify best analysis strategies
Study design
Power analysis
Sample size

23. Biostatistics Training & Mentoring
Students
Masters Theses
Doctoral Dissertations
Colleagues
Physician-Scientists in Training
K-12 Awards

24. Other Services (fee for service)
For existing funded projects the Biostatistics Center can provide on a fee for service basis:
SAS Programming
Statistical Analysis
Manuscript Preparation
Report Generation
Data Base Development

25. Conclusion
The CICATS Biostatistics Center is available for assisting investigators in all phases of their research. We look forward to collaborations with researchers.
James Grady, DrPH

26. CICATS Clinical Research Center
Clinical Research Center (CRC)

27. Mission
The CRC is a comprehensive center providing services in support of high-quality patient-oriented research at the UConn Health Center and affiliated hospitals.
Goals
Provide a wide range of administrative, clinical, laboratory and data management services for federally funded, foundation-funded, and industry-supported studies
Ensure the ethical treatment and safety of research subjects and the scientific merit of clinical studies

28. Clinical Research Center
Complete “Appendix A” form
Apply as either: 1. Partially-funded (pay 80%) or 2. Fee-for-service (pay 100% of the cost of the requested service)
Core Directors available to discuss a project’s specific needs
Applying for CRC resources

29. Clinical Research Center
Study Coordination
RN/RA/MA Services
Dental Operatory
DEXA (Bone Densities)
Recruitment
IRB/IND/CoC Application
Clinical Core

30. Clinical Research Center
Sample Processing and Storage
DNA and RNA Isolation
Protein Analysis by Immunoassay (Elisas/RIAs)
Genotyping and RNA Analysis
Core Lab Services

31. Clinical Research Center
Database consultation
Double data entry
Case Report Form design
Interactive Voice Response (IVR) survey creation and management
Custom application development
Informatics Services

32. CICATS Education & Training
Master of Science in Clinical & Translational Research Program
Anne Kenny, MD, Program Director

33. Master of Science in Clinical & Translational Research Program Goals
Competitively prepares health care professionals with academic and research skills needed for independent research.
Focus: Preparation of individuals with established, terminal degrees in a health related field (MD, PhD, Pharm.D., DDS or DMD) to conduct independent research in translation of information from the basic sciences to the community as researchers, teachers, public health administrators, clinicians, and industry employees competent to carry out the broad health mission of the State of Connecticut.

34. THANK YOU…