Presentation is loading. Please wait.

Presentation is loading. Please wait.

Aminoacylation of Proteins: New Targets for the Old ARSenal

Published byRoar Mikkelsen Modified over 6 years ago

Similar presentations

Presentation on theme: "Aminoacylation of Proteins: New Targets for the Old ARSenal"— Presentation transcript:

1 Aminoacylation of Proteins: New Targets for the Old ARSenal
Seyed Mehdi Jafarnejad, Sung-Hoon Kim, Nahum Sonenberg  Cell Metabolism  Volume 27, Issue 1, Pages 1-3 (January 2018) DOI: /j.cmet Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Dual Role of ARSs in Aminoacylation of tRNAs and Proteins
Left: aminoacylation of tRNA by ARSs. The 3′ end of tRNAs are charged with amino acids using activated aminoacyl-adenylate intermediates by ARSs. The aminoacylated tRNA is recruited to the ribosome during mRNA translation. Right: aminoacylation of lysine residues in proteins by ARSs. The high-energy aminoacyl-adenylate intermediate is charged onto lysine residues in proteins by ARSs. Lysine aminoacylation impacts substrate-specific functions in diverse physiological processes. Lysine aminoacylation is reversible by removing the aminoacyl group from the lysine by NAD+-dependent deacetylases. Cell Metabolism  , 1-3DOI: ( /j.cmet ) Copyright © 2017 Elsevier Inc. Terms and Conditions

Download ppt "Aminoacylation of Proteins: New Targets for the Old ARSenal"

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.
SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages 224-235 (January.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.
Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages 241-253 (March 2014) DOI: 10.1016/j.cell.2014.02.012 Copyright.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.
What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages 20-44 (January 2014) DOI: 10.1016/j.cell.2013.12.012.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages 226-240 (August 2014) DOI: 10.1016/j.cmet.2014.07.001.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet
Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.
Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation Sunil Laxman, Benjamin M. Sutter, Xi.

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation Sunil Laxman, Benjamin M. Sutter, Xi.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages 38-52 (April 2008) DOI: 10.1016/j.cell.2008.03.011.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.

Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome Corinne Ferrier Maurice, Henry Joseph Haiser, Peter James Turnbaugh.
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.
Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,
The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.
Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages 248-252 (April 2010) DOI: 10.1016/j.cmet.2010.03.008 Copyright © 2010.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.
The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages 558-573 (April.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.
Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages 838-850 (June 2013) DOI:

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:
Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.
Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages 11-22.

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages
One Strike against Low-Carbohydrate Diets

One Strike against Low-Carbohydrate Diets

Similar presentations

Ads by Google