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Unveiling the Role of Senescence-Induced Cellular Plasticity

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1 Unveiling the Role of Senescence-Induced Cellular Plasticity
Jumpei Taguchi, Yasuhiro Yamada  Cell Stem Cell  Volume 20, Issue 3, Pages (March 2017) DOI: /j.stem Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 In Vivo Reprogramming Reveals a Link between Cellular Plasticity and Senescence In vivo induction of reprogramming factors triggers two divergent cellular outcomes, cellular reprogramming and damage-induced cellular senescence. Senescence-associated secretory phenotype (SASP), particularly IL-6, promotes in vivo reprogramming, suggesting that SASP enhances cellular plasticity in tissue. These findings could have implications for rejuvenation, tissue regeneration, and cancer development in multicellular organisms. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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