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Clinical picture and treatment of 2212 patients with common variable immunodeficiency  Benjamin Gathmann, MA, Nizar Mahlaoui, MD, MSc, MPH, Laurence Gérard,

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Presentation on theme: "Clinical picture and treatment of 2212 patients with common variable immunodeficiency  Benjamin Gathmann, MA, Nizar Mahlaoui, MD, MSc, MPH, Laurence Gérard,"— Presentation transcript:

1 Clinical picture and treatment of 2212 patients with common variable immunodeficiency 
Benjamin Gathmann, MA, Nizar Mahlaoui, MD, MSc, MPH, Laurence Gérard, MD, Eric Oksenhendler, MD, Klaus Warnatz, MD, Ilka Schulze, MD, Gerhard Kindle, MD, Taco W. Kuijpers, MD, Rachel T. van Beem, PhD, David Guzman, Lic, Sarita Workman, RN, MSc, Pere Soler-Palacín, MD, PhD, Javier De Gracia, MD, PhD, Torsten Witte, MD, Reinhold E. Schmidt, MD, Jiri Litzman, MD, Eva Hlavackova, MD, Vojtech Thon, MD, PhD, Michael Borte, MD, PhD, Stephan Borte, MD, Dinakantha Kumararatne, MD, Conleth Feighery, MD, Hilary Longhurst, FRCP, PhD, Matthew Helbert, MD, Anna Szaflarska, MD, Anna Sediva, MD, Bernd H. Belohradsky, MD, Alison Jones, MRCP, PhD, Ulrich Baumann, MD, PhD, Isabelle Meyts, MD, PhD, Necil Kutukculer, MD, Per Wågström, MD, Nermeen Mouftah Galal, MD, Joachim Roesler, MD, Evangelia Farmaki, MD, PhD, Natalia Zinovieva, MD, Peter Ciznar, MD, PhD, Efimia Papadopoulou-Alataki, MD, PhD, Kirsten Bienemann, MD, Sirje Velbri, MD, PhD, Zoya Panahloo, MD, Bodo Grimbacher, MD  Journal of Allergy and Clinical Immunology  Volume 134, Issue 1, Pages e11 (July 2014) DOI: /j.jaci Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Age at onset of symptoms in the total cohort (n = 1914), among female patients (n = 985), and among male patients (n = 929). B, Age at diagnosis in the total cohort (n = 2134), among female patients (n = 1094), and among male patients (n = 1040). An age of 0 years means less than 12 months of age. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Frequency of clinical features in our cohort (n = 902). Numbers in bars represent the absolute number of patients per feature. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Kaplan-Meier graph depicting patient survival in relation to age at diagnosis. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Health outcomes in correlation to IgG trough levels. The “n” within each bar is the total number of subjects having the indicated median IgG level. A, Patients with serious bacterial infections. B, Patients hospitalized because of immunodeficiency. Because the total number of serious infections and days in the hospital were low, the graph shows the percentage of affected patients. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 A, Age at onset of symptoms for ages 0 to 10 years. B, Age at diagnosis for ages 0 to 10 years. Journal of Allergy and Clinical Immunology  , e11DOI: ( /j.jaci ) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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