1. AMISTAD II: Study Design
2,118 patients with anterior infarction, double blind randomized trial
High Dose Adenosine
70 µg/kg/min for 3 hours
Low Dose Adenosine
50 µg/kg/min for 3 hours
Placebo + + +
Thrombolysis or PCI
Thrombolysis or PCI
Thrombolysis or PCI
Infarct Size 120 –168 hours
Death/CHF at 6 months

2. AMISTAD II: Primary Endpoint
All Patients
Reperfusion
Success
Reperfusion
Failure
P=0.043
P=NS
P=NS
Death/CHF at 6 months (%)
Death/CHF at 6 months (%)
Adenosine
Pooled
Adenosine
High Dose
Placebo
Adenosine
Placebo
Adenosine
Placebo

3. AMISTAD II: Primary Endpoint by Time from Symptom Onset
< 2 Hours
2 - 4 Hours
> 4 Hours
Death/CHF at 6 months (%)
Adenosine
Placebo
Adenosine
Placebo
Adenosine
Placebo

4. AMISTAD II: Infarct Size
P=0.078
P=0.028
Adenosine
Pooled
Adenosine
High Dose
Adenosine
Low Dose
Placebo