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THE ENDOCANNABINOID SYSTEM AND CARDIOMETABOLIC RISK

Published byInger Danielsen Modified over 6 years ago

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Presentation on theme: "THE ENDOCANNABINOID SYSTEM AND CARDIOMETABOLIC RISK"— Presentation transcript:

1 THE ENDOCANNABINOID SYSTEM AND CARDIOMETABOLIC RISK
Excess food intake - obesity Overactivity of the EC system Brain CB1 Gastrointestinal tract ? Food intake CB1 Genetic susceptibility? Abdominal adiposity FFA Liver Adipocytes Skeletal muscle? Adiponectin FFA CB1 TNF-α CB1 CB1 IL-6 CRP Lipogenesis LPL Lipogenesis Impaired insulin action Liver fat VLDL Glucose production Insulinemia Insulin degradation Apo AI synthesis Glucose intolerance Increased waist (abdominal obesity) Insulin resistance High triglyceride-low HDL choIesteroI dyslipidemia Pro-inflammatory profile Risk of CVD and type 2 diabetes Adapted from Després JP et al. Int J Obes 2006; 30: S44-52

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