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FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels  Pan-Yue Deng, Ziv.

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Presentation on theme: "FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels  Pan-Yue Deng, Ziv."— Presentation transcript:

1 FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels  Pan-Yue Deng, Ziv Rotman, Jay A. Blundon, Yongcheol Cho, Jianmin Cui, Valeria Cavalli, Stanislav S. Zakharenko, Vitaly A. Klyachko  Neuron  Volume 78, Issue 1, (April 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure E1 ISI Rounding Effect in Measurements of Action Potential Duration with 60 Hz Stimulation (A and B) Action potential duration was recorded in eight WT CA3 pyramidal cells using 60 Hz trains (A,  ms ISI pattern) or 58.8 Hz trains (B,  ms ISI pattern), demonstrating that the three-point periodicity in the measurements is due to rounding of fractional 16.67 ms ISIs at 60 Hz. Note that the first AP of the burst is treated as baseline AP. (C) Overlay of data from (A) and (B). Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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