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Inosine Triphosphate Pyrophosphatase and Thiopurine S-Methyltransferase Genotypes Relationship to Azathioprine-Induced Myelosuppression Zuzana Zelinkova, Luc J.J. Derijks, Pieter C.F. Stokkers, Esther W.M. Vogels, Antoine H.C. van Kampen, Wouter L. Curvers, Danny Cohn, Sander J.H. van Deventer, Daniël W. Hommes Clinical Gastroenterology and Hepatology Volume 4, Issue 1, Pages (January 2006) DOI: /j.cgh Copyright © 2006 American Gastroenterological Association Terms and Conditions
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Figure 1 Proposed thiopurine metabolism.
Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions
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Figure 2 TPMT genotypes. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions
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Figure 3 Location of the 5 single-nucleotide polymorphisms on the ITPA gene. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions
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Figure 4 Percentages of ITPA and TPMT (*3A or *3C) mutant allele carriers among AZA users with respect to the development of leukopenia. *P = .046; OR = 3.504; 95% CI, 1.119–10.971; **P = .004; OR = 6.316; 95% CI, 2.141– ■, Wild type; □, mutant allele carriers. Clinical Gastroenterology and Hepatology 2006 4, 44-49DOI: ( /j.cgh ) Copyright © 2006 American Gastroenterological Association Terms and Conditions
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