1. Time to Relax: Mechanical Stress Release Guides Stem Cell Responses
Sven D. Sommerfeld, Jennifer H. Elisseeff 
Cell Stem Cell 
Volume 18, Issue 2, Pages (February 2016)
DOI: /j.stem
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Dynamics of Matrix Mechanical Cues Guide Stem Cell Behavior
Stem cells integrate spatiotemporal signals from their microenvironment, e.g., the mechanical properties of the matrix. Within an elastic matrix (most synthetic hydrogels), the energy from mechanical stresses is stored within the static network, just like in a loaded spring. In turn, in viscoelastic matrices (tissues and reversible hydrogels), the stored energy is released by stress-relaxation, modeled as a loaded spring with a damper. Stress-relaxation constitutes a dynamic, mechanical cue guiding signaling within the stem cell, thus modulating spreading, polarization, and differentiation.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2016 Elsevier Inc. Terms and Conditions