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Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients  Philippe Geissbühler, MD,

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Presentation on theme: "Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients  Philippe Geissbühler, MD,"— Presentation transcript:

1 Elevated Serum Vitamin B12 Levels Associated With CRP as a Predictive Factor of Mortality in Palliative Care Cancer Patients  Philippe Geissbühler, MD, Bernadette Mermillod, BSc, Charles-Henri Rapin, MD  Journal of Pain and Symptom Management  Volume 20, Issue 2, Pages (August 2000) DOI: /S (00)00169-X

2 Fig 1 Overall survival, first year. Vertical lines correspond to 95% confidence intervals Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

3 Fig. 2a Survival according to B12, first year. Vertical lines correspond to 95% confidence interval Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

4 Fig. 2b Survival according to B12, five years. Trend test =6.066 (df=1) p = .014 Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

5 Fig. 3a Survival according to BCI, first year. Vertical lines correspond to 95% confidence interval Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

6 Fig. 3b Survival according to BCI, five years. Trend test = (df=1) p < Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

7 Fig. 4 Relation between B12, CRP, and Survival. This figure gives a scatterplot of CRP and B12, with observations denoted by circles with area proportional to length of survival. The two lines represent a BCI (CRP multiplied by B12) of 10,000 for the lower one and 40,000 for the upper one. The gray circle represents the only survivor Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)

8 Fig. 5 Relationship between PINI and CRP, r = 0.96
Journal of Pain and Symptom Management  , DOI: ( /S (00)00169-X)


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