1. Arteriotomy closure by glued patch in the porcine carotid artery
Jacqueline Bastiaanse, MD, Cornelius Borst, MD, PhD, Yvonne J.M van der Helm, Karine H.H Loo, Paul F Gründeman, MD, PhD 
The Annals of Thoracic Surgery 
Volume 70, Issue 4, Pages (October 2000)
DOI: /S (00)

2. Fig 1
Schematic drawing of application of tissue adhesive. (A) A small amount of tissue adhesive was applied to the artery adjacent to the arteriotomy and then glue was covered by patch. (B) Tissue adhesive was applied to the patch before covering the arteriotomy
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

3. Fig 2
Schematic representation of a cross-section of an arteriotomy, 4 weeks postoperatively. The arteriotomy gap was filled with a layer of repair tissue (dark gray).The area bordered by the lumen and the internal elastic lamina was defined as intimal hyperplasia. In the repaired arteriotomy gap, the part that exceeded the estimated inner circumference of the artery was considered luminal intimal hyperplasia.
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

4. Fig 3
At 2 days: transverse cross-section of an arteriotomy closed by tissue adhesive and patch. No medial necrosis was observed in the vicinity of the application site of tissue adhesive (Hematoxylin and eosin stain; original magnification, × 40), (p = patch; bar = 500 μm.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )

5. Fig 4
At 4 weeks: transverse cross-section of an arteriotomy closed by tissue adhesive and patch. (A) The arteriotomy gap has been filled with repair tissue. Note the normal lining of the inner circumference of the artery without luminal intimal hyperplasia. The void between patch and vessel wall used to contain cyanoacrylate, which has been dissolved during histologic processing (Elastin van Gieson stain; original magnification, × 40). (p = patch; bar = 500 μm.) (B) Cyanoacrylate (arrow) was still present (Oil-Red-O stain; original magnification, × 40). (p = patch; bar = 500 μm.)
The Annals of Thoracic Surgery  , DOI: ( /S (00) )