1. Prevotella as a Hub for Vaginal Microbiota under the Influence of Host Genetics and Their Association with Obesity 
Jiyeon Si, Hyun Ju You, Junsun Yu, Joohon Sung, GwangPyo Ko 
Cell Host & Microbe 
Volume 21, Issue 1, Pages (January 2017)
DOI: /j.chom
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2. Cell Host & Microbe 2017 21, 97-105DOI: (10.1016/j.chom.2016.11.010)
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3. Figure 1 Transition of the Vaginal Microbiota Dependent on Host States
(A) Proportion of top ten genera in different vaginal conditions. Pre, premenopause; post, postmenopause; BV, bacterial vaginosis; HPV, HPV infection; Obese, BMI ≥ 30.
(B) Non-metric multidimensional scaling (NMDS) plot of the vaginal microbiota based on health conditions (vectors). A black arrow denotes a strong correlation and a dotted arrow denotes a non-significant correlation. Points represent the vaginal microbiota at all taxonomic levels; colors indicate the menopausal state. NA, not available.
(C) Microbial diversity in the vagina according to BMI. Lean: BMI 18.5–24.9; obese: BMI ≥ 30. ∗p < 0.05 based on Wilcoxon rank-sum test.
Cell Host & Microbe  , DOI: ( /j.chom )
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4. Figure 2 Host Genetic Effects on the Vaginal Microbiota
(A) Unweighted UniFrac distances of twin pairs, twins and sisters, twins and mothers, and unrelated individuals. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < based on Student’s t test.
(B) Twin-pair intraclass correlation coefficients for the microbiota at different taxonomic levels. Dotted lines indicate group means.
(C) Top ten heritability estimates of the vaginal microbiota. H2r, heritability estimates.
(D) Bar graph of the heritability estimates calculated using host physiology. Clinical data were adjusted and transformed for covariates (age, menopause, and hormone therapy). Error bars indicate SE.
(E) Association of interleukin-5 (IL-5) with P. melaninogenica and concentrations of white blood cells (WBCs). Boxes represent the 25th percentile, median, 75th percentile, and mean (diamond). Whiskers represent the lowest and highest values of the host phenotypes, excluding outliers. See also Figure S1.
Cell Host & Microbe  , DOI: ( /j.chom )
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5. Figure 3 Associations of the Vaginal Microbiota with Host Health
Significant changes in vaginal bacteria analyzed by multivariate association with linear models (MaAsLin) accounting for twin pairs, BMI, hormone therapy, human papilloma virus (HPV) infection, cervicitis, and bacterial vaginosis (BV). Menopause (A), BV (B), and BMI (C). See also Figures S2 and S3.
Cell Host & Microbe  , DOI: ( /j.chom )
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6. Figure 4 Co-occurrence Analysis of the Vaginal Microbiota
Co-occurring bacteria at the genus level in premenopausal (A) and postmenopausal (B) women with normal vaginal conditions. Size and color of the nodes represent relative abundance of the vaginal microbiota and heritability estimates, respectively. Solid line in orange and dotted line in gray denote positive and negative correlations, respectively. The width reflects the strength of the correlation.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2017 Elsevier Inc. Terms and Conditions