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One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years  Reem Ahmed Elfeky, MD, Juliana M. Furtado-Silva,

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Presentation on theme: "One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years  Reem Ahmed Elfeky, MD, Juliana M. Furtado-Silva,"— Presentation transcript:

1 One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years  Reem Ahmed Elfeky, MD, Juliana M. Furtado-Silva, MD, Robert Chiesa, MD, Kanchan Rao, MRCPCH, MNAMS, Persis Amrolia, FRCP, PhD, FRCPath, Giovanna Lucchini, MD, Kimberly Gilmour, PhD, Stuart Adams, PhD, Shahnaz Bibi, PhD, Austen Worth, MD, PhD, Adrian J. Thrasher, MD, PhD, Waseem Qasim, MBBS, PhD, Paul Veys, FRCP, FRCPath  Journal of Allergy and Clinical Immunology  Volume 142, Issue 5, Pages e7 (November 2018) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 A and B, Platelet recovery after transplantation. **P < .05 and ***P < .001. B, Boxes represent patients who had donor myeloid engraftment below 50% and were splenectomized. Plt, Platelet. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © Terms and Conditions

3 Fig 2 A-C, Kinetics of donor engraftment. P8 had a drop in donor T-cell engraftment to 13% at 6 months posttransplant, this was followed by a sustained higher donor T-cell engraftment above 70% from 1 year posttransplant till last follow-up (Fup). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © Terms and Conditions

4 Fig E1 Effect of donor T-cell and myeloid cell engraftment and posttransplantation autoimmunity. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © Terms and Conditions

5 Fig E2 Probability of clinical and immunologic complications among 34 patients with WAS. Complications included post-transplant autoimmunity, need for a second intervention, chronic GvHD, post-transplant splenectomy, reduced vision (post-CMV retinitis), bronchiectasis and secondary malignancy. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © Terms and Conditions


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