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Shigella Targets T Cells

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Presentation on theme: "Shigella Targets T Cells"— Presentation transcript:

1 Shigella Targets T Cells
John L. Telford, Cosima T. Baldari  Cell Host & Microbe  Volume 9, Issue 4, Pages (April 2011) DOI: /j.chom Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Impairment of T Cell Chemotaxis by Shigella
Schematic representation of the mechanism by which Shigella IpgD impairs T cell migration. Shigella injects the lipid phophatase IpgD into the cytosol of activated CD4+ T cells, causing a reduction in the cortical pool of PIP2 and inactivation of the membrane-cytoskeleton linker ezrin, which results in defective chemotaxis. Cell Host & Microbe 2011 9, DOI: ( /j.chom ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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