1. Chirally Selective Solvation of R,S-BNDHP by Cholate Micelles
Exploit atomic specificity of NMR:
H4-H8 : sample hydrophobic interior of cholate micelles
H5-H7 : experience chirally selective environments
H3 : exposed on micellar surface (Note : H8 partially surface exposed) H5
7 mM H6 H7
Aggregate States by NMR: H3
15 mM
7 mM
H4-H8 have a hydrophobic interaction with a preliminary aggregate that forms at 7 mM cholate, which is conserved in all subsequent aggregates of cholate
A primary cholate micelle forms at 15 mM cholate.
Further aggregation occurs ca mM cholate. (data not shown) H3
15 mM H8 H8
7 mM