1. Volume 147, Issue 2, Pages 267-269 (August 2014)
Mutational Signatures in Helicobacter pylori–induced Gastric Cancer: Lessons From New Sequencing Technologies 
Sarah Derks 
Gastroenterology 
Volume 147, Issue 2, Pages (August 2014)
DOI: /j.gastro
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2. Figure 1
Two pathways of C>T mutation in gastric cancer. (Above arrow) Activation-induced deamination (AID) removes the amino group of cytosine turning it into uracil. (Below arrow) Cytosine methylation induced deamination. The binding of a methyl group to the 5-carbon position of the cytosine ring results in 5-methylcytosine. A 5-methylcytosine spontaneously deaminates into an uracil. The uracil is replaced by a thymine after DNA replication.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2014 AGA Institute Terms and Conditions