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Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide–Associated Verner-Morrison Syndrome  Keith W. Pratz, MD, Cynthia Ma, MD, Marie-Christine.

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Presentation on theme: "Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide–Associated Verner-Morrison Syndrome  Keith W. Pratz, MD, Cynthia Ma, MD, Marie-Christine."— Presentation transcript:

1 Large Cell Carcinoma With Calcitonin and Vasoactive Intestinal Polypeptide–Associated Verner-Morrison Syndrome  Keith W. Pratz, MD, Cynthia Ma, MD, Marie-Christine Aubry, MD, Terri J. Vrtiska, MD, Charles Erlichman, MD  Mayo Clinic Proceedings  Volume 80, Issue 1, Pages (January 2005) DOI: / Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Chest x-ray film on admission shows normal findings except for postoperative changes of the vertebrectomy. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 Chest computed tomogram shows nodules in 2 slices of the right upper lung. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

4 Figure 3 Left, Intermediate-power photomicrograph of malignant neoplasm within paratracheal lymph node shows lack of glandular or squamous differentiation. The cells are large and pleomorphic with areas of necrosis (hematoxylin-eosin, original magnification ×100). Right, Neoplastic cells, diffusely positive for chromogranin, show neuroendocrine differentiation by immunohistochemistry (chromogranin, original magnification ×100). Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions

5 Figure 4 Endocrine tumor markers. Initiation of chemotherapy was on hospital day 11. We observed a substantial decline in tumor marker levels within 3 days. VIP = vasoactive intestinal polypeptide. Mayo Clinic Proceedings  , DOI: ( / ) Copyright © 2005 Mayo Foundation for Medical Education and Research Terms and Conditions


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