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Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis  I.M. Leonie Majoie,

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Presentation on theme: "Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis  I.M. Leonie Majoie,"— Presentation transcript:

1 Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis  I.M. Leonie Majoie, MD, J. Marja Oldhoff, MD, PhD, Huib van Weelden, MSc, Marloes Laaper-Ertmann, Mente T. Bousema, MD, Vigfus Sigurdsson, MD, PhD, Edward F. Knol, PhD, Carla A.F. Bruijnzeel-Koomen, MD, PhD, Marjolein S. de Bruin-Weller, MD, PhD  Journal of the American Academy of Dermatology  Volume 60, Issue 1, Pages (January 2009) DOI: /j.jaad Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Trial flow chart. During the treatment period phototherapy was administered 3 times/wk; patients were randomly assigned to receive narrowband ultraviolet (UV) B to one side of the body and medium-dose UVA1 to the other side. LSS, Leicester sign score; VAS, visual analog scale. Journal of the American Academy of Dermatology  , 77-84DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Clinical results. Mean reduction in Leicester sign score (LSS) (A) and visual analog scale (VAS) pruritus (B). No significant difference in favor of narrowband (NB) ultraviolet (UV) B. MD, Medium dose; X-axes, time in weeks; Y-axes, mean score. Vertical lines display SD. Journal of the American Academy of Dermatology  , 77-84DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Immunohistochemical results (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was with narrowband (NB) ultraviolet (UV) B and other body side with medium-dose (MD) UVA1. AA1, Mast cell; elastase, neutrophil; CD1a, dendritic cell; CD3, T cell; EG2, eosinophil; X-axes, time: 0 = lesional skin, 8 = after 8 weeks of phototherapy; Y-axes, cells/mm2. ∗Significantly different decrease in cells compared with t = 0. No significant differences were observed between NB UVB and MD UVA1 sides. Journal of the American Academy of Dermatology  , 77-84DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Immunohistochemical results of forkhead box protein P3 (n = 9). Cellular infiltrate before (t = 0) and after (t = 8) phototherapy in patients with atopic dermatitis. Treatment of one body side was with narrowband (NB) ultraviolet (UV) B and other body side with medium-dose (MD) UVA1. CD3, T cell; FoxP3, positive T cell; X-axes, time: 0 = lesional skin, 8 = after 8 weeks of phototherapy; Y-axes, cells/mm2. ∗Significant decrease in cells compared with t = 0. No significant differences were observed between NB UVB and MD UVA1 sides. Journal of the American Academy of Dermatology  , 77-84DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

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