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Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher.

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Presentation on theme: "Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher."— Presentation transcript:

1 Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency  Jonathan P. Lane, MBBS, Christopher J. Stewart, PhD, Stephen P. Cummings, PhD, Andrew R. Gennery, MD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 2, Pages e3 (August 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 PLS-DA showing separation of metabolite profiles by pre- or post-HSCT status. X/Y overview values for pre- and post-HSCT: R2 = 0.77, Q2 = 0.6; values >0.5 demonstrate data passes validation and are robust and reproducibly predictive of pre- and post-HSCT grouping. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Level 2 PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states) analysis for patients A (A), B (B), and D (C). T (blue)—day of HSCT. N (green)—neutrophil engraftment. Conditioning (yellow): Treo/flu/C1H—treosulfan, fludarabine, Campath. Antibiotics (black): T—teicoplanin; M—meropenem; S—co-trimoxazole; C—ceftazidime; V—vancomycin; A—amikacin; Aug—co-amoxiclav. Clinically significant complications noted (orange). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Level 3 PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states) analysis for bacterial cell motility expression (A-C) and membrane transport expression (D-E) for patients A, B, and D. T (blue)—day of HSCT. N (green)—day of neutrophil engraftment. Conditioning (yellow): Treo/flu/C1H—treosulfan, fludarabine, Campath. Antibiotics (black): T—teicoplanin; M—meropenem; S—co-trimoxazole; C—ceftazidime; V—vancomycin; A—amikacin; Aug—co-amoxiclav. Clinically significant complications noted (orange). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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