1. The cancer stem cell concept in cancer progression and metastasis
Figure 1 from Sancho et al.
British Journal of Cancer Advance Online Publication
24 May 2016 doi: /bjc
Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies.
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