1. DNA Maintenance

3. Replication Errors

5. Single Base Mutations
1 / 105
60,000/genome

6. 1 / 107
600/genome

7. DNA Polymerase d

8. Remove/replace G
Remove/replace A

9. 1 / 109
6/genome

10. Insertional Mutations

12. Spontaneous Damage

13. Deamination
GC  AT

14. De-purination
6 x 106 purines lost/day
6 x 104 pyrimidines lost/day

15. GC  AT
GC  AT

17. Exposure

18. Alkylating Agents

19. Adducts

22. Mutagen

35. p53
RINT 1

36. Other Processes with which BRCA-1 has been Associated
Transcription (binds to transcriptional activators)
Heterochromatin formation (binds to an H2A ubiquitin ligase)
Cell Motility (localized to the cell cortex)
Mitosis (localized to centrosomes)