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Neuroanatomical Assessment of Biological Maturity
Timothy T. Brown, Joshua M. Kuperman, Yoonho Chung, Matthew Erhart, Connor McCabe, Donald J. Hagler, Vijay K. Venkatraman, Natacha Akshoomoff, David G. Amaral, Cinnamon S. Bloss, B.J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, Walter E. Kaufmann, Tal Kenet, David N. Kennedy, Sarah S. Murray, Elizabeth R. Sowell, Terry L. Jernigan, Anders M. Dale Current Biology Volume 22, Issue 18, Pages (September 2012) DOI: /j.cub Copyright © 2012 Elsevier Ltd Terms and Conditions
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Figure 1 Individual Measures Derived from the T1-Weighted Imaging Protocol Example measures derived from the segmentation of the T1-weighted volume are plotted for 885 subjects as a function of age: total cortical area in square millimeters by thousands, mean cortical thickness in millimeters, volume of the left hippocampus in cubic millimeters by thousands, and volume of the right thalamus in cubic millimeters by thousands. Colors correspond to different sites and scanners. Symbol size represents subject sex (larger = female, smaller = male). A spline-fit curve (solid line) with 5% and 95% prediction intervals (dashed lines) are also shown. Current Biology , DOI: ( /j.cub ) Copyright © 2012 Elsevier Ltd Terms and Conditions
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Figure 2 Individual Measures Derived from the T2- and Diffusion-Weighted Imaging Protocols Example measures derived from the T2- and diffusion-weighted protocols are plotted for 885 subjects as a function of age: T2-normalized (T2N) signal intensity of left uncinate fibers; apparent diffusion coefficient (ADC) of the corpus callosum; ADC of the right superior longitudinal fasciculus (SLF); and fractional anisotropy (FA) of the left caudate nucleus. Colors correspond to different sites and scanners. Symbol size represents subject sex (larger = female, smaller = male). A spline-fit curve (solid line) with 5% and 95% prediction intervals (dashed lines) are also shown. Current Biology , DOI: ( /j.cub ) Copyright © 2012 Elsevier Ltd Terms and Conditions
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Figure 3 Multimodal Quantitative Anatomical Prediction of Age
For 885 individuals, estimated brain age is plotted as a function of actual chronological age. Colors correspond to different sites and scanners. Symbol size represents subject sex (larger = female, smaller = male). A spline-fit curve (solid line) with 5% and 95% prediction intervals (dashed lines) is also shown. Current Biology , DOI: ( /j.cub ) Copyright © 2012 Elsevier Ltd Terms and Conditions
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Figure 4 Age-Varying Contributions of Different Imaging Measures to the Prediction of Age The relative contributions of separate morphological, diffusivity, and signal intensity measures within different brain structures are plotted as a function of age. Colors correspond to measure and structure type (dark blue, T1 cortical area; green, T1 cortical thickness; red, T1 subcortical volumes; light blue, diffusion (FA/ADC) within white matter tracts; dark pink, diffusion (FA/ADC) within subcortical ROIs; gold, T2 signal intensity within white matter tracts; black, T2 signal intensity within subcortical ROIs). Contributions are computed as units of the proportion of total explained variance. Current Biology , DOI: ( /j.cub ) Copyright © 2012 Elsevier Ltd Terms and Conditions
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