1. Volume 128, Issue 5, Pages 1160-1171 (May 2005)
Immunohistochemical Analysis Reveals High Frequency of PMS2 Defects in Colorectal Cancer 
Kaspar Truninger, Mirco Menigatti, Judith Luz, Anna Russell, Ritva Haider, Jan-Olaf Gebbers, Fridolin Bannwart, Hueseyin Yurtsever, Joerg Neuweiler, Hans-Martin Riehle, Maria Sofia Cattaruzza, Karl Heinimann, Primo Schär, Josef Jiricny, Giancarlo Marra 
Gastroenterology 
Volume 128, Issue 5, Pages (May 2005)
DOI: /j.gastro
Copyright © 2005 American Gastroenterological Association Terms and Conditions

2. Figure 1
Immunohistochemical staining of colorectal tumors for MMR proteins. (A) MLH1 is absent from tumor tissue, but normal crypts (upper part of the picture) and proliferating stromal cells express this protein normally. (B) The same tumor does not express PMS2, because this protein is unstable in the absence of MLH1. However, other MMR proteins are expressed normally, as shown for MSH2 (inset). (C) The dysplastic crypts on the right side of this tumor express MLH1 levels similar to the normal crypts on the left; (D) however, the dysplastic crypts are deficient in PMS2.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

3. Figure 2
Immunohistochemical staining of a colon adenoma and extracolonic cancers for the MMR proteins MLH1 and PMS2. PMS2 is not expressed in the 2 mildly dysplastic crypts of a 2-mm benign colon adenoma (upper panels, asterisks; higher magnification is shown in the right panel; case of Table 3), in a prostate carcinoma (middle panels; case 20498), and in a squamous cell carcinoma (lower panels; case 61162). Note that, in the latter 2 samples, PMS2 is expressed in nonneoplastic tissues and MLH1 is expressed in both normal tissue and tumor tissue.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions