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Development In time In space
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End result... Too complicated
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End result... much simpler Bacillus sporulation Anabaena heterocysts
Myxobacteria fruiting Caulobacter cell cycle
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Bacillus subtilis Temporally regulated differentiation
Start Restart Pause
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Caulobacter crescentus Cell cycle-regulated differentiation
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Anabaena Spatially regulated differentiation
Time after nitrogen removal 0 h 3 h 6 h 9 h 12 h
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Myxococcus xanthus Socially regulated differentiation
Feast Famine
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Route to altered states in bacteria
Bacillus, Anabaena, Myxococcus Starvation Permissive conditions Initiation Altered State Signal transduction pH, Fe,... Pathogens
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