1. 生化重點整理
生科2A 第17組
毛儒毅 0993B007
梁育銓 0993B036

2. 心智圖 GTP Rx 5: Succinyl-CoA Synthetase Succinyl-CoA Synthetase FAD
Rx6: Succinate Dehydrogenase
Oxaloacetate Regenerated
electron
Rx 7:Fumarase atalyzes form L-Malate
H2O
NAD+
Rx8: Malate Dehydrogenase Oxidizing Malate to Oxaloacetate
part 2.
TCA cycle 2
G=+30
How Is the TCA Cycle Regulated?

3. Rx 5: Succinyl-CoA Synthetase

4. Rx6: Succinate Dehydrogenase Is FAD-Dependent
This enzyme is actually part of the electron
transport pathway in the inner mitochondrial
membrane

5. Rx 7: Fumarase Catalyzes the Trans-Hydration of Fumarate to Form L-Malate
Hydration across the double bond

6. Rx8: Malate Dehydrogenase Completes the Cycle by Oxidizing Malate to Oxaloacetate
An NAD+-dependent oxidation
Go' of +30 kJ/mol

7. How Is the TCA Cycle Regulated?
Citrate synthase - ATP, NADH and succinyl-
CoA inhibit
Isocitrate dehydrogenase - ATP inhibits, ADP
and NAD+ activate
Ketoglutarate dehydrogenase - NADH and
succinyl-CoA inhibit, AMP activates
Also note pyruvate dehydrogenase: ATP,
NADH, acetyl-CoA inhibit, NAD+, CoA activate

8. The citrate synthase synthase reaction initiates the TCA cycle

9. Pyruvate regulation