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PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

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Presentation on theme: "PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic"— Presentation transcript:

1 PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic
Lesley A. Kane, Richard J. Youle  Cell  Volume 147, Issue 4, Pages (November 2011) DOI: /j.cell Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Miro in Mitochondrial Autophagy
(A) In cells with healthy mitochondria, Miro and its binding partners connect mitochondria to microtubules, facilitating trafficking of the organelles to various cellular locations. (B) Upon mitochondrial damage, PINK1 levels are stabilized on the outer membrane, resulting in the recruitment of Parkin and modification of Miro. The inset shows the PINK1/Parkin/Miro complex described by Wang et al. (C) Through phosphorylation, ubiquitination, and proteasomal pathways, Miro is degraded. The stationary damaged mitochondrion is segregated and can then undergo mitophagy. Cell  , DOI: ( /j.cell ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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