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Volume 386, Issue 9996, Pages (August 2015)

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Presentation on theme: "Volume 386, Issue 9996, Pages (August 2015)"— Presentation transcript:

1 Volume 386, Issue 9996, Pages 857-866 (August 2015)
Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial  Ana Maria Henao-Restrepo, MD, Prof Ira M Longini, PhD, Prof Matthias Egger, MD, Natalie E Dean, PhD, Prof W John Edmunds, PhD, Anton Camacho, PhD, Miles W Carroll, PhD, Moussa Doumbia, MD, Bertrand Draguez, MD, Sophie Duraffour, PhD, Godwin Enwere, FWACP, Rebecca Grais, PhD, Stephan Gunther, MD, Stefanie Hossmann, MSc, Prof Mandy Kader Kondé, PhD, Souleymane Kone, MSc, Eeva Kuisma, PhD, Prof Myron M Levine, MD, Sema Mandal, MD, Gunnstein Norheim, PhD, Ximena Riveros, BSc, Aboubacar Soumah, MD, Sven Trelle, MD, Andrea S Vicari, PhD, Conall H Watson, MFPH, Sakoba Kéïta, MD, Dr Marie Paule Kieny, PhD, Prof John-Arne Røttingen, MD  The Lancet  Volume 386, Issue 9996, Pages (August 2015) DOI: /S (15) Copyright © 2015 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Terms and Conditions

2 Figure 1 Study area of Ebola ça Suffit cluster vaccination trial in Basse-Guinée The Lancet  , DOI: ( /S (15) ) Copyright © 2015 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Terms and Conditions

3 Figure 2 Trial profile The Lancet  , DOI: ( /S (15) ) Copyright © 2015 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Terms and Conditions

4 Figure 3 Kaplan-Meier plots of the cumulative incidence of confirmed Ebola virus disease in different study populations (A) All vaccinated individuals assigned to immediate vaccination versus all eligible individuals assigned to delayed vaccination (primary analysis). (B) All eligible and consenting individuals. (C) All eligible individuals. (D) All individuals. Arrows indicate immediate (day 0) and delayed (day 21) vaccination. The shaded area shows the period excluded from analyses. The Lancet  , DOI: ( /S (15) ) Copyright © 2015 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Terms and Conditions


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