1. Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy 
W. Nathaniel Brennen, John T. Isaacs 
Cancer Cell 
Volume 32, Issue 4, Pages (October 2017)
DOI: /j.ccell
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Prostate Cell Lineage, Cancer-Initiating Cells, and Therapeutic Selection
Overview of the cellular subtypes within the hierarchically expanding stem cell organization of the normal human prostate epithelial compartment based on the characteristic self-renewal potential, proliferation rate, and phenotypic marker expression. Magnitude of self- renewal potential versus proliferation rate for each subtype is indicated by the number of “+” signs, indicating increasing values, and “−” signs, indicating a zero value. Phenotypic markers are: androgen receptor (AR), prostate-specific antigen (PSA), TP63, and neuroendocrine (NE) genes (i.e., chromogranin A, synaptophysin, etc.), with superscript “+” indicating expression and superscript “−” indicating no expression.
Cancer Cell  , DOI: ( /j.ccell )
Copyright © 2017 Elsevier Inc. Terms and Conditions