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Archana Singh, Pankaj Sharma, Hemanta K. Kar, Vinod K. Sharma, Manoj K

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Presentation on theme: "Archana Singh, Pankaj Sharma, Hemanta K. Kar, Vinod K. Sharma, Manoj K"— Presentation transcript:

1 HLA Alleles and Amino-Acid Signatures of the Peptide-Binding Pockets of HLA Molecules in Vitiligo 
Archana Singh, Pankaj Sharma, Hemanta K. Kar, Vinod K. Sharma, Manoj K. Tembhre, Somesh Gupta, Naresh C. Laddha, Mitesh Dwivedi, Rasheedunnisa Begum, The Indian Genome Variation Consortium, Rajesh S. Gokhale, Rajni Rani  Journal of Investigative Dermatology  Volume 132, Issue 1, Pages (January 2012) DOI: /jid Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

5 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

6 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions

7 Figure 1 Amino-acid signatures for the peptide-binding pockets of HLA molecules. (a) For DR β1-chain in vitiligo patients from North India and Gujarat. Amino acids shown in red are significantly increased in vitiligo patients; amino acids shown in green are significantly reduced in vitiligo patients as compared with controls. More than one amino acid at certain positions being red or green suggests the involvement of multiples alleles. (b) Ribbon diagram for peptide-binding clefts for predisposing and (c) protective DRB1 alleles (using PyMOL software, PyMOL Molecular Graphics System, Schrödinger, San Carlos, CA). (d) Amino-acid signature for HLA-A locus. (e) Amino-acid signature for HLA-B locus in vitiligo. Significantly increased P<0.009 to 10−29; Significantly increased P<0.05–0.01; Significantly reduced P<0.009 to 10−28; Significantly reduced P<0.05–0.01; Nonsignificant. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2012 The Society for Investigative Dermatology, Inc Terms and Conditions


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