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Lauren E. Higdon, Michael P. Cancro  Immunity 

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Presentation on theme: "Lauren E. Higdon, Michael P. Cancro  Immunity "— Presentation transcript:

1 Caught Off Center: Rethinking the Requirements for Antibody Affinity Maturation 
Lauren E. Higdon, Michael P. Cancro  Immunity  Volume 43, Issue 1, Pages 5-6 (July 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Alternative Routes and Locales for Antibody Affinity Maturation Top: In a conventional T cell-dependent response, B cells activated by avid BCR engagement receive cognate T cell help and form GCs, where their interactions with FDCs and Tfh enable rounds of somatic hypermutation and selection that yield high-affinity plasma and memory B cells. Bottom: The response to STm initiates with comparatively low affinity B cells, which undergo SHM and affinity maturation in the absence of GCs. Immunity  , 5-6DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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