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Distribution of Biopsy-Proven Presumed Primary Glomerulonephropathies in Among a Racially and Ethnically Diverse US Population John J. Sim, MD, Michael Batech, DrPH, Aviv Hever, MD, Teresa N. Harrison, SM, Taurino Avelar, MD, Michael H. Kanter, MD, Steven J. Jacobsen, MD, PhD American Journal of Kidney Diseases Volume 68, Issue 4, Pages (October 2016) DOI: /j.ajkd Copyright © 2016 The Authors Terms and Conditions
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Figure 1 Study population flow diagram. In January 1, 2000, through December 31, 2011, a total of 4,440 Kaiser Permanente Southern California members had a kidney biopsy. Among this cohort, 369 were younger than 18 years and 308 had inconclusive biopsy results. Another 138 had a history of systemic lupus erythematous, and 1,124 were either transplant biopsies or findings revealing secondary glomerulonephropathy (GN). Thus, 2,501 individuals with primary glomerulonephropathy were included in the study cohort. American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2016 The Authors Terms and Conditions
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Figure 2 The distribution of primary glomerulonephropathy in the 12-year observation window. Focal segmental glomerulosclerosis (FSGS) rates, and to a lesser degree immunoglobulin A (IgA) nephropathy rates, increased throughout the period. Minimal change disease and membranous glomerulonephritis rates remained flat throughout our observation period. The “other” category included immune complex glomerulonephritis not otherwise specified, pauci-immune/antineutrophil cytoplasmic antibody–associated glomerulonephritis, thin basement membrane disease, membranoproliferative glomerulonephritis, crescentic glomerulonephritis not otherwise specified, postinfectious glomerulonephritis, anti–glomerular basement membrane disease, fibrillary glomerulonephritis, dense deposit disease, and others. American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2016 The Authors Terms and Conditions
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Figure 3 Average annual age- and sex-adjusted rates for the most common primary glomerulonephropathy disease states by race and ethnicity, 2000 to Rates for the primary glomerulonephropathy and by different race and ethnic groups were similar to the distribution for the entire period. Abbreviations: FSGS, focal segmental glomerulosclerosis; IgA, immunoglobulin A. American Journal of Kidney Diseases , DOI: ( /j.ajkd ) Copyright © 2016 The Authors Terms and Conditions
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