1. Multimodal Approaches to the Management of Neuropathic Pain: The Role of Topical Analgesia 
Oscar A. de Leon-Casasola, MD 
Journal of Pain and Symptom Management 
Volume 33, Issue 3, Pages (March 2007)
DOI: /j.jpainsymman
Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
Molecular and cellular modifications associated with central sensitization. GABA=γ-aminobutyric acid, GLY=glycine, NMDA=N-methyl-d-aspartate, AMPA=α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, BDNF=brain-derived neurotrophic factor, PKC=protein kinase C, NSC=nonspecific cation channels, VGCC=voltage-gated calcium channel, TrkB=tyrosine kinase B receptor, IP3=inositol 1,4,5-trisphosphate, NK1=neurokinin-1, mGluR=mammalian glutamate receptor, EP=prostaglandin E2 receptor. Adapted from Ref. 1.
Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman )
Copyright © 2007 U.S. Cancer Pain Relief Committee Terms and Conditions