1. 10 December 2010 Sign up for exam day and time:
Take Abstract: Grading 50% Original, 50% Revision.
Sign up for exam day and time:
Tuesday 2-5, Thursday or Friday 9-12
Take handout: The Response to Ingestion of 800 ml of isotonic saline (7g NaCl in water)
Check website & for notifications regarding
exam and potential essay questions.
Times when you can review test folders

2. Acid-Base Balance A little more on Clearance:
Clearance of glucose = 0 ml/min which means….
Clearance of X = 120 ml/min which means….
Clearance of antibiotic XXX = 500 ml/min which means…
Lung-kidney connection
Acid-Base Balance

3. Any changes in ventilation after you vomit?

4. Figure 14.31
Normally, all filtered bicarbonate is “reabsorbed”

5. Figure 14.32 This process is increased during metabolic acidosis
Excess H+ eliminated in urine bound to phosphate buffer.

6. Figure 14.33 This process is increased during metabolic acidosis
Filtration
Reabsorption
Secretion
Metabolism
Metabolism of glutamine in tubular cells generate bicarbonate buffer.
This process is increased during metabolic acidosis

7. Who Cares?

8. Father-in-law with emphysema (respiratory case studies lab)
PaCO2 =30 mmHg, PaO2 = 60 mmHg plasma pH = 7.47
Hyperventilating: ventilation in excess of metabolism to compensate for loss of alveolar surface area for diffusion of O2
Commensurate loss of CO2
RESPIRATORY ___________
Renal compensation……… retain ___ and eliminate _____
Review 3 previous slides.

9. Loss of HCl in vomitus would be compensated by……..

11. The End? Reincarnation