1. Neutrophil / Lymphocyte ratio (NLR)
Abstract ID: 
Moderated Poster - MP26
Pre-operative
Neutrophil / Lymphocyte ratio (NLR)
as a prognosticator in upper tract urothelial carcinoma (UTUC) patients treated conservatively:
A retrospective evaluation
Defidio L1, De Dominicis M1, Di Gianfrancesco L2,, Antonucci M1, Patel A3
1Cristo Re Hospital, Dept. of Urology, Rome, Italy
2Catholic School of Medicine, Rome, Italy
3London, UK

2. WBC, PLT, N, L counts. (NLR = N / L).
Preoperative Neutrophil / Lymphocyte ratio (NLR) as a prognosticator in upper tract urothelial carcinoma (UTUC) patients treated conservatively: A retrospective evaluation
NLR = expression of the involvement of systemic inflammation in neoplasia
130 consecutive patients.
WBC, PLT, N, L counts. (NLR = N / L).
Comparison with tumor characteristics: Grade, Stage, Focality, Site, Size.
Endpoints:
Recurrence at 1st follow-up
Multiple recurrences during follow-up
Progression (Grade +/- Stage)

3. Preoperative Neutrophil / Lymphocyte ratio (NLR) as a prognosticator in upper tract urothelial carcinoma (UTUC) patients treated conservatively: A retrospective evaluation
Mean NLR value = 3.48 ± 1.92
Optimum cut-off NLR value: 3 (for all endpoints) – ROC analysis
Higher NLR values in:
≥pT1 (p=0.0001)
HG (p=0.0009)
Multifocal (p=0.028)
>1 cm tumor (p=0.0001)
Patients with NLR >3 exhibited
Risk of recurrence at 1st F-U p=0.007, OR 2.94
Risk of multiple recurrences p=0.006, OR 1.54
Risk of disease progression p=0.04, OR 5
Pre-operative NLR evaluation may provide valuable prognostic information for the selection, clinical management, and surveillance of UTUC patients selected for, or choosing conservative treatment.