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Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation  S. Roullet, J. Pillot, G. Freyburger,

Published byΦιλόθεος Παπακωνσταντίνου Modified over 6 years ago

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Presentation on theme: "Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation  S. Roullet, J. Pillot, G. Freyburger,"— Presentation transcript:

1 Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation  S. Roullet, J. Pillot, G. Freyburger, M. Biais, A. Quinart, A. Rault, P. Revel, F. Sztark  British Journal of Anaesthesia  Volume 104, Issue 4, Pages (April 2010) DOI: /bja/aeq022 Copyright © 2010 The Author(s) Terms and Conditions

2 Fig 1 Evolution of clot amplitude at 10 min (A10) of EXTEM during the OLT. *P<0.004 vs T0. Data are shown as box plots with median represented by horizontal line with the 75th percentile at the top and the 25th at the bottom. The 10th and 90th percentiles are shown as whiskers. T0, after induction of general anaesthesia; T1, during hepatectomy; T2, anhepatic stage; T3, 30–60 min after graft revascularization; T4, end of surgery; T5, 24 h after surgery. British Journal of Anaesthesia  , DOI: ( /bja/aeq022) Copyright © 2010 The Author(s) Terms and Conditions

3 Fig 2 Correlation between (a) clot amplitude at 10 min (A10) of EXTEM and platelet count, (b) A10 of EXTEM and Fg concentration, and (c) A10 of FIBTEM and Fg concentration. British Journal of Anaesthesia  , DOI: ( /bja/aeq022) Copyright © 2010 The Author(s) Terms and Conditions

4 Fig 3 Multiple linear regression for EXTEM A10. A10, clot amplitude at 10 min. Predicted EXTEM A10=17.53–0.83×Hb+1.323E−04×Plt+ 6.16×Fg−0.14×ATIII−5.75E−04×DD+0.15×FX+1.19E−02×ELT. Hb, haemoglobin (g dl−1); Plt, platelets (mm−3); Fg, fibrinogen (g litre−1); ATIII, antithrombin III (%); DD, D-dimers (µg litre−1); FX, factor X (%); ELT, euglobulin lysis time (min). British Journal of Anaesthesia  , DOI: ( /bja/aeq022) Copyright © 2010 The Author(s) Terms and Conditions

5 Fig 4 ROC curves of EXTEM A10 for predicting thrombocytopenia under mm−3 and Fg concentration under 1 g litre−1. British Journal of Anaesthesia  , DOI: ( /bja/aeq022) Copyright © 2010 The Author(s) Terms and Conditions

6 Fig 5 (a) Normal ROTEM® tracing. (b) ROTEM® tracing depicting severe coagulation abnormalities with hyperfibrinolysis corrected by the addition of aprotinin (APTEM). British Journal of Anaesthesia  , DOI: ( /bja/aeq022) Copyright © 2010 The Author(s) Terms and Conditions

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