2. Tumor Immunity
——卓越一班 二组——

3. Introduction
We may forget the past
But the past won't forget us

4. Tumor Antigen A B TSA: Tumor-specific antigen
TAA: Tumor-associated antigen

5. Tumor Antigen CEA --Carcinoembryonic antigen --A kind of TAA
--It can be used as a tumor marker in clinical tests

6. Elimination
--The innate and adaptive immune system together detect and destroy early tumors
--Before tumors become clinically visible.

7. Escape CTLA-4: --Cytotoxic T lymphocyte-associated antigen-4
--Combine with B7
--Participate in immunosuppression
PD-L1(CD274):
--Programmed death-ligand 1
--Combine with
PD-1
--Participate in immunosuppression

8. Immunoediting Elimination Equilibrium Escape Resist immune recognition
Induce immune
suppression
Intimate immunity
Adaptive immunity

9. Treatment
DC-CIK
--A kind of adoptive
immunotherapy
--Is obsolete

10. Treatment CAR-T --CAR: chimeric antibody receptor
--Is sufficient to promote T cell proliferation, CK production and target cell cytolysis

11. Treatment
PD-1--PD-L1/2
CTLA-4/CD28--B7

12. Tecentriq
--The first and only FDA-approved anti-PDL1 cancer immuotherapy
--Treat patients with locally advanced or metatatic urothelial carcinoma(mUC)

13. C Summary Introduction Tumor antigen Imunoediting Treatment 01 02 0304
Treatment

14. Discussion
“Antioxidant can lead cancer, and ROS during radiotherapy can kill cancer cells.”
“But, if we use the natural ROS which is produced by our own bodies, the side-effect will no longer be considered. ”
James Watson

15. How many years must a patient fight
Before he is free from pills
How many pains must a patient stand
Before he finally heals
How many torments must a patient suffer
Before the tumor is removed forever
The answer my friends, is lying in our hands
The answer is lying in our hands
How many years will we wait
Before scientists figure out the method
To cure cancer which is efficient
How many mistakes will we meet
Till we eventually find out the treatment
For every cancer of each patient
The answer my friends, is lying in our hands The answer is lying in our hands
---- By Group 2

16. Thank You