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Dana Branzei, Marco Foiani  Cell 

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Presentation on theme: "Dana Branzei, Marco Foiani  Cell "— Presentation transcript:

1 Template Switching: From Replication Fork Repair to Genome Rearrangements 
Dana Branzei, Marco Foiani  Cell  Volume 131, Issue 7, Pages (December 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Fork Repair and Chromosomal Rearrangements by Template Switching Replication forks encountering DNA lesions (red star) on the template strand can engage the nascent chains into template switching to bypass the DNA lesion. Forks encountering low-copy repeats or repetitive elements are prone to stalling and, occasionally, switch templates in the presence of a nearby template at another fork, thus generating chromosomal rearrangements. This process might require regions of microhomology (red bars). Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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