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Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits…

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Presentation on theme: "Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits…"— Presentation transcript:

1 Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits…
Barna Dey, Edward A. Berger  Structure  Volume 21, Issue 6, Pages (June 2013) DOI: /j.str Copyright © 2013 Elsevier Ltd Terms and Conditions

2 Figure 1 The Phe43 Cavity CD4 (pink; only domain 1 is shown) binding induces formation of an ∼150 Å3 interfacial pocket at the nexus of the gp120 inner domain (pale blue), outer domain (marine blue), and bridging sheet (purple); the phenyl ring of the Phe43 side chain (red) forms a lid to the cavity and is the only contributing component from CD4. This image was generated using MacPyMOL from Protein Data Bank number 1RZK (Huang et al., 2004). Structure  , DOI: ( /j.str ) Copyright © 2013 Elsevier Ltd Terms and Conditions


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