1. Dysfunctional Families: Clostridium scindens and Secondary Bile Acids Inhibit the Growth of Clostridium difficile 
K. Leigh Greathouse, Curtis C. Harris, Scott J. Bultman 
Cell Metabolism 
Volume 21, Issue 1, Pages 9-10 (January 2015)
DOI: /j.cmet
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2. Figure 1
S. scindens and Secondary Bile Acids Inhibit C. difficile Growth
(Left) In the absence of antibiotics, the gut microbial community is diverse and includes bacteria such as S. scindens that convert primary bile acids into secondary bile acids, which, in turn, inhibits the growth of C. difficile. (Right) Broad-spectrum antibiotics diminish the diversity of the gut microbial community. Loss of certain bacteria such as C. scindens results in reduced production of secondary bile acids and increased growth of C. difficile. Additionally, accumulation of primary bile acids leads to increased spore germination of C. difficile.
Cell Metabolism  , 9-10DOI: ( /j.cmet )
Copyright © 2015 Elsevier Inc. Terms and Conditions