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Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia
Kirsi Jahnukainen, M.D., Ph.D., Risto Heikkinen, M.D., Markus Henriksson, M.D., Ph.D., Trevor G. Cooper, Ph.D., Leena-Riitta Puukko- Viertomies, M.D., Ph.D., Outi Mäkitie, M.D., Ph.D. Fertility and Sterility Volume 96, Issue 4, Pages (October 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
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Figure 1 (A) Testicular volume and (B) total sperm count compared with the control group and acute lymphoblastic leukemia (ALL) survivors without testicular irradiation. Closed dots represent survivors with prophylactic cranial irradiation. P values are compared with the control group. Testis volume: control vs. cyclophosphamide 0 g/m2, P=.24; vs. ≤10 g/m2, P=.001; vs. >20 g/m2, P=.003. Total sperm count: control vs. cyclophosphamide 0 g/m2, P=.84; vs. ≤10 g/m2, P=.90; vs. >20 g/m2, P=.004. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
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Figure 2 Cumulative fertility rates of first-fathered child by age of the father. The values for the 28-year and 33-year rates are mean ± standard error of the mean. TI = testicular irradiation ± cyclophosphamide. Controls vs. cyclophosphamide >20 g/m2 or TI, P<.05. Cyclophosphamide 0–10 g/m2 vs. >20 g/m2 or TI, P<.05. Fertility and Sterility , DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
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