1. Unraveling the Pros and Cons of Interferon-γ Gene Regulation
Howard A. Young 
Immunity 
Volume 24, Issue 5, Pages (May 2006)
DOI: /j.immuni
Copyright © 2006 Elsevier Inc. Terms and Conditions

2. Figure 1
Schematic Representation of the Differential Effects of IL-12, IL-18, and TGF-β on Expression of IFN-γ by NK Cells
IL-12 and IL-18 treatment downregulates the ability of NK cells to respond to TGF-β through downregulation of one chain of the TGF-β receptor and the TGF-β-activated transcription factors SMAD2 and SMAD3. In contrast, TGF-β downregulates IFN-γ expression though inhibition of the transcription factor T-bet and direct interaction of the SMAD proteins with the IFN-γ promoter.
Immunity  , DOI: ( /j.immuni )
Copyright © 2006 Elsevier Inc. Terms and Conditions