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Idiopathic Pulmonary Fibrosis: Evolving Concepts
Jay H. Ryu, MD, Teng Moua, MD, Craig E. Daniels, MD, Thomas E. Hartman, MD, Eunhee S. Yi, MD, James P. Utz, MD, Andrew H. Limper, MD Mayo Clinic Proceedings Volume 89, Issue 8, Pages (August 2014) DOI: /j.mayocp Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 1 Histopathologic features of usual interstitial pneumonia. A, Low-power view shows marked fibrosis with architectural distortion, honeycombing in a predominantly subpleural distribution with absence of features inconsistent with usual interstitial pneumonia, eg, granulomas, marked inflammation, organizing pneumonia (hematoxylin-eosin, original magnification ×40). B, High-power view shows fibroblast foci, focal pale areas of active fibroblast proliferation at the edge of dense fibrosis (hematoxylin-eosin, original magnification ×100). Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 2 High-resolution computed tomographic features of usual interstitial pneumonia. A, Axial view shows subpleural predominance of reticular opacities and honeycombing with absence of features inconsistent with a usual interstitial pneumonia pattern, eg, extensive ground-glass opacities, consolidation, micronodules, mosaic pattern (air trapping). B, Sagittal view shows subpleural and basilar predominance of reticular opacities and honeycombing. Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions
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Figure 3 High-resolution computed tomographic features of acute exacerbation in idiopathic pulmonary fibrosis. Diffuse ground-glass opacities are seen bilaterally, greater on the right, superimposed on underlying usual interstitial pneumonia characterized by reticular opacities and honeycombing in the subpleural tissues. Mayo Clinic Proceedings , DOI: ( /j.mayocp ) Copyright © 2014 Mayo Foundation for Medical Education and Research Terms and Conditions
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