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Cancer and the Immune System

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Presentation on theme: "Cancer and the Immune System"— Presentation transcript:

1 Cancer and the Immune System
Cell  Volume 149, Issue 1, (March 2012) DOI: /j.cell Copyright © Terms and Conditions

2 Expression of engineered TSAs (measured by luciferase activity) is lost during sarcoma development in immunocompetent mice (left), whereas TSA expression is retained in the sarcomas if T cells are depleted during tumor development (right). Figure courtesy of M. DuPage and T. Jacks. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

3 Cancer immunoediting sculpts tumors by causing downregulation of tumor-specific antigens. Cartoon by K. Mahan. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

4 (Left) The preinfusion contrast-enhanced CT scan shows multiple enlarged 1–3 cm axillary lymph nodes (example highlighted by arrows). (Right) Scan at day 104 shows resolution of enlarged lymph nodes, consistent with a complete response. Image courtesy of D.L. Porter. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions

5 Differential tumor growth in mice that received irrelevant antibodies (top) vs. depleting anti-CD8 (bottom). Figure courtesy of M. Rutkowski, U. Scarlett, and J. Conejo-Garcia. Cell  , DOI: ( /j.cell ) Copyright © Terms and Conditions


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