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Volume 44, Issue 5, Pages (May 2006)

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Presentation on theme: "Volume 44, Issue 5, Pages (May 2006)"— Presentation transcript:

1 Volume 44, Issue 5, Pages 947-955 (May 2006)
The finest branches of the biliary tree might induce biliary vascularization necessary for biliary regeneration  Marius C. van den Heuvel, Annette S.H. Gouw, Marcel Boot, Maarten J.H. Slooff, Sibrand Poppema, Koert P. de Jong  Journal of Hepatology  Volume 44, Issue 5, Pages (May 2006) DOI: /j.jhep Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 Portal tract of a control patient at reperfusion (A), 1-week (B) and 1-year (C). Biliary epithelium is stained in red, endothelium is stained in brown. (A) and (C): normal bile ducts (black arrow) and bile ductules (black arrowheads) with escorting microvasculature. (B): damaged bile duct (black arrow). Bile ductules without escorting microvessels (white arrowheads) are increased. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 Portal tract of a CR patient at reperfusion (A), 1-month (B) and 1-year (C). Biliary epithelium is stained in red, endothelium is stained in brown. (A): normal bile ducts (black arrow) and bile ductules (black arrowheads) with escorting microvasculature. (B): bile duct (white arrow) and only two bile ductules (white arrowheads) without escorting microvasculature. (C): damaged bile ducts without escorting microvessels (white arrows). Absence of bile ductules. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

4 Fig. 3 Portal tract of a control patient at reperfusion (A) and 1-week (B). (A): bile duct (black arrow) and bile ductules (black arrowheads) showing a weak positive staining for VEGF-A. (B): bile duct (black arrow) and bile ductules (black arrowheads) in the control group at 1-week showing strong positive staining for VEGF-A In both figures hepatocytes show a weak membranous expression. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

5 Fig. 4 Boxplots showing numbers of bile ducts with capillaries (A), without capillaries (B) and total number of bile ducts (C) per portal tract at reperfusion (RPB), 1-week (1-W), 1-month (1-M) and 1-year (1-Y) in CR and the controls. (A): *, lower in CR at 1-year (reperfusion P=0.012; 1-week P=0.021). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

6 Fig. 5 Boxplots showing numbers of bile ductules with microvessels (A), without microvessels (B) and the total number of bile ductules (C) per portal tract at reperfusion (RPB), 1-week (1-W), 1-month (1-M) and 1-year (1-Y) in CR and the controls. (A): *, lower in CR at 1-year (reperfusion P=0.004; 1-week P=0.005; 1-month P=0.028); #, higher in controls at 1-month (reperfusion P=0.049; 1-year P=0.007). (B): #, higher in controls at 1-week (reperfusion P=0.003; 1-month P=0.036; 1-year P=0.001); ##, higher in controls at 1-month (reperfusion P=0.011; 1-year P=0.002). (C): *, lower in CR at 1-year (reperfusion P=0.006; 1-week P=0.007; 1-month P=0.015); #, higher in controls at 1-week (reperfusion P=0.026; 1-year P=0.008); ##, higher in controls at 1-month (reperfusion P=0.017; 1-year P=0.003). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

7 Fig. 6 Boxplots showing numbers of extraportal biliary cells with microvessels (A), without microvessels (B) and the total number of extraportal biliary cells (C) per portal tract at reperfusion (RPB), 1-week (1-W), 1-month (1-M) and 1-year (1-Y) in CR and the controls. (A): *, higher in CR at reperfusion (1-week P=0.01; 1-year P=0.003); **, higher in CR at 1-month (1-year P=0.038). (C): *, higher in CR at reperfusion (1-week P=0.05; 1-year P=0.006); **, higher in CR at 1-month (1-year P=0.041). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

8 Fig. 7 Boxplots showing the total portal (A) and extraportal (B) microvascular compartment. (A): #, lower in controls at 1-week (reperfusion P=0.006); ##, higher in controls at 1-month (reperfusion P=0.003; 1-week P=0.03); ###, lower in controls at 1-year (1-month P=0.02). (B): *, higher in CR at reperfusion (1-week P=0.034; 1-month P=0.005); #, higher in controls at reperfusion (1-week P=0.002; 1-month P<0.001); ##, higher in controls at 1-year (1-month P=0.007). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

9 Fig. 8 Line graphs representing the median values of the counted portal structures with exception of bile ducts per portal tract in time. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

10 Fig. 9 Line graphs representing the median values of the extraportal counted structures per portal tract in time. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions


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