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Figure 3 Differentiation and functional control of T-cell subsets

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1 Figure 3 Differentiation and functional control of T-cell subsets
Figure 3 | Differentiation and functional control of T-cell subsets. Naive CD4+ T cells differentiate into T-helper (TH) type 1, TH2, TH 17, T regulatory (Treg), and T follicular helper (TFH) cell subsets, whereas naive CD8+ T cells differentiate into cytotoxic T lymphocytes (CTL) and double negative (DN) T cells. The transcription factors and cytokines that contribute to each of the different T-cell subtypes are indicated. Targetable molecules that may control certain differentiation pathways are shown in blue ovals; factors that stimulate development of the different T-cell subtypes are shown in purple boxes and transcription factors are shown in blue boxes. APC, antigen presenting cell; CaMKIV, calcium/calmodulin-dependent protein kinase IV; IFNγ, interferon γ; ROCK, Rho-associated protein kinase; TGFβ, transforming growth factor β. Suárez-Fueyo, A. et al. (2017) T cells and autoimmune kidney disease Nat. Rev. Nephrol. doi: /nrneph

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